Manganese-catalyzed synthesis of 4-CF3-2-phosphinoylquinolines via radical 6-endo-trig cyclization of 1-Isocyano-2-(1-(trifluoromethyl)ethenyl)benzenes

A manganese-catalyzed radical 6-endo-trig cyclization of 1-isocyano-2-(1-(trifluoromethyl) ethenyl)benzenes with arylphosphine oxides which involved a novel Mn(III)/Mn(II) catalytic circle, has been developed. The reaction afforded various 4-CF3-2-phosphinoylquinolines under mild reaction conditions without any external oxidant, ligand or additive.