[Practice guidelines of thromboprophylaxis and management of anticoagulation in hospitalized patients with COVID-19].

Corona virus disease 2019 (COVID-19) can lead to thrombotic complications through multiple mechanisms. Venous thromboembolism (VTE) is one of the most important causes of death or poor prognosis in hospitalized patients with COVID-19. The prognosis of thrombosis in COVID-19 patients can be improved with VTE and bleeding risk assessment, as well as appropriate VTE prophylaxis. However, in current clinical practice, there still is much room for progress in choose of appropriate prevention methods, anticoagulant regimens, doses, and courses based on the severity and specific condition of COVID-19 patients and dynamically balancing the risk of thrombosis and bleeding. In the past three years, a series of authoritative guidelines related to VTE and COVID-19 and high-quality, evidence-based medical research evidence have been released both in domestic and internationally. Based on this, in order to better guide the clinical practice in China, multi-discipline expert discussions and Delphi expert demonstrations formulated the"Thromboprophylaxis and management of anticoagulation in hospitalized patients with COVID-19: an update of the CTS guidelines", aiming to address the issues of thrombosis risk and prevention strategies caused by COVID-19, anticoagulant management of hospitalized patients, diagnosis and treatment of thrombosis, anticoagulant management of special populations, interaction and adjustment strategies of antiviral and anti-inflammatory drugs and anticoagulant drugs, follow-up after discharge and many other aspects of clinical situations. Recommendations and clinical guidelines are provided for appropriate thromboprophylaxis and anticoagulation management strategies for VTE in patients with COVID-19.新型冠状病毒感染（COVID-19）可通过多种机制引发血栓并发症，其中静脉血栓栓塞症（VTE）是导致COVID-19住院患者死亡或预后不佳的重要原因之一。采用合理的风险评估模型对COVID-19患者进行VTE及出血风险评估，并按照风险级别实施规范的预防措施可显著改善COVID-19患者血栓相关不良预后。然而在目前的临床实践中，如何根据COVID-19患者严重程度及具体病情选择恰当的预防方式、抗凝方案、剂量和疗程，动态平衡血栓和出血风险，仍有很大的提升空间。近年来，国际已发布系列COVID-19合并VTE相关权威指南及高质量循证医学研究证据，基于此，为更好地指导我国医护人员的临床实践，经过多学科专家研讨和德尔菲专家论证，工作组牵头制订了《新型冠状病毒感染住院患者血栓预防和抗凝管理指南》，针对COVID-19引起的血栓风险和预防策略、住院患者的抗凝管理、血栓诊治、特殊人群的抗凝管理、抗病毒和抗炎药物与抗凝治疗药物的相互作用和调整策略、出院后随访等诸多方面的临床核心问题进行了阐述，以期明确对不同临床分型COVID-19患者及特殊人群的合理预防和抗凝管理策略，为我国COVID-19患者VTE防治提供推荐意见和临床指导。.