Debugging neurodevelopment disorders

Gut bacteria are thought to contribute to neurodevelopmental disorders, but whether they are causal or predictive of disease remains unclear. In a prospective longitudinal study of thousands of children, Ahrens et al. generate evidence for the role of the gut microbiome in neurodevelopmental disorders while highlighting important open questions. Gut bacteria are thought to contribute to neurodevelopmental disorders, but whether they are causal or predictive of disease remains unclear. In a prospective longitudinal study of thousands of children, Ahrens et al. generate evidence for the role of the gut microbiome in neurodevelopmental disorders while highlighting important open questions. Infant microbes and metabolites point to childhood neurodevelopmental disordersAhrens et al.CellApril 3, 2024In BriefThis prospective, birth cohort multi-omic study reveals disruptions in the infant gut microbiome associated with later-diagnosed neurodevelopmental disorders. Microbial and metabolomic changes, correlating with risk factors, HLA genetics, and mood/gastrointestinal issues, support the hypothesis of early-life origins of neurodevelopmental disorders, underscoring an important role of gut microbiota. Full-Text PDF Open Access