吞噬作用
细胞生物学
生物
巨噬细胞
髓样
微生物学
化学
免疫学
生物化学
体外
作者
Benjamin Y. Winer,Alexander Settle,Alexandrina M. Yakimov,Carlos Jeronimo,Tomi Lazarov,Murray J. Tipping,Michelle Saoi,Anjelique Sawh,Anna-Liisa L. Sepp,Michael Galiano,Justin S. A. Perry,Yung Yu Wong,Frédéric Geissmann,Justin R. Cross,Ting Zhou,Lance C. Kam,H. Amalia Pasolli,Tobias M. Hohl,Jason G. Cyster,Orion D. Weiner,Morgan Huse
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2024-06-07
卷期号:9 (96)
被引量:3
标识
DOI:10.1126/sciimmunol.adl2388
摘要
Professional phagocytes like neutrophils and macrophages tightly control what they consume, how much they consume, and when they move after cargo uptake. We show that plasma membrane abundance is a key arbiter of these cellular behaviors. Neutrophils and macrophages lacking the G protein subunit Gβ 4 exhibited profound plasma membrane expansion, accompanied by marked reduction in plasma membrane tension. These biophysical changes promoted the phagocytosis of bacteria, fungus, apoptotic corpses, and cancer cells. We also found that Gβ 4 -deficient neutrophils are defective in the normal inhibition of migration following cargo uptake. Sphingolipid synthesis played a central role in these phenotypes by driving plasma membrane accumulation in cells lacking Gβ 4 . In Gβ 4 knockout mice, neutrophils not only exhibited enhanced phagocytosis of inhaled fungal conidia in the lung but also increased trafficking of engulfed pathogens to other organs. Together, these results reveal an unexpected, biophysical control mechanism central to myeloid functional decision-making.
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