合成生物学
天然产物
系统生物学
模块化设计
计算生物学
生物
生物技术
生化工程
生物化学
计算机科学
工程类
操作系统
作者
Jucan Gao,Yuanwei Gou,Lei Huang,Jiazhang Lian
标识
DOI:10.1016/j.copbio.2024.103136
摘要
Plant natural products (PNPs) are a diverse group of chemical compounds synthesized by plants for various biological purposes and play a significant role in the fields of medicine, agriculture, and industry. In recent years, the development of synthetic biology promises the production of PNPs in microbial expression systems in a sustainable, low-cost, and large-scale manner. This review first introduces multiplex genome editing and PNP pathway assembly in microbial expression systems. Then recent technologies and examples geared toward improving PNP biosynthetic efficiency are discussed from three aspects: pathway optimization, chassis optimization, and modular coculture engineering. Finally, the review is concluded with future perspectives on the combination of machine learning and BioFoundry for the reconstitution and optimization of PNP microbial cell factories.
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