代谢组学
代谢组
背景(考古学)
仿形(计算机编程)
肝硬化
医学
生物信息学
计算生物学
数据科学
生物
计算机科学
内科学
操作系统
古生物学
作者
Yanqun Luo,Caiyun Zhang,Xia-zhen Nong,Ying Gao,Lei Wang,Guang Ji,Tao Wu
标识
DOI:10.1016/j.cca.2024.117886
摘要
Liver cirrhosis (LC) represents a significant hepatic disorder that persistently commands the attention of the scientific community, especially concerning its pathogenesis and therapeutic approaches. Metabolomics, the comprehensive profiling of an organism's metabolome, has been increasingly applied in the research of cirrhosis over the past decade. This review summarizes the recent advancements and applications of metabolomics within the context of LC research, in recent five years. It highlights the role of metabolomics in the diagnosis of LC, the assessment of prognostic markers, and the evaluation of therapeutic outcomes. The discussion focuses on the potential and challenges of metabolomics in LC research, including the evolution of analytical technologies, advancements in bioinformatics, and the challenges impeding clinical implementation. Additionally, the review anticipates the forthcoming developments in metabolomics related to LC research, with the objective of facilitating innovative approaches for early detection and intervention in LC.
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