膜
润湿
材料科学
接触角
化学工程
微型多孔材料
蛋白质吸附
吸附
热稳定性
表面改性
膜污染
傅里叶变换红外光谱
结垢
色谱法
高分子化学
化学
复合材料
聚合物
有机化学
生物化学
工程类
作者
Xiujuan Zhang,Zelin Liao,Xinlu Zhang,Xuehua Ruan,Hao Gong,Xiaokun Wang,Wenji Zheng,Yan Dai,Gaohong He
标识
DOI:10.1016/j.seppur.2024.127501
摘要
Excellent hemocompatibility and long-term stability against blood wetting are important properties required for artificial lung membrane, the core component in extracorporeal membrane oxygenator which is life-saving for patients with severe lung dysfunctions. Herein, novel hydrophilic modified polyethersulfone (PES) asymmetric membranes were synthesized via thermal cross-linking, and characterization via SEM, FTIR, 1HNMR and surface water contact angle measurements demonstrated that the modified asymmetric membranes composing a dense layer with hydrophilic surface on top of a microporous support layer were successfully fabricated without any observed defects. Among all the modified membranes, PEGylated PES membrane exhibited the smoothest membrane surface, improved mechanical property, good gas permeability and the best performance in hemocompatibility in terms of blood coagulation, protein adsorption and platelet adhesion. Moreover, the PEGylated PES membrane showed excellent long-term stability in membrane surface wettability as well as long-term stable performance against blood fouling and wetting. This research work provides valuable insights and new idea into synthesizing membranes, with simple synthesis process, long lasting high hemocompatibility and stability against wetting, for application as artificial lung membranes.
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