GPX4
程序性细胞死亡
疾病
活性氧
细胞生物学
生物
细胞
肠上皮
癌症研究
医学
氧化应激
上皮
细胞凋亡
遗传学
生物化学
病理
过氧化氢酶
谷胱甘肽过氧化物酶
作者
Juan-José Escuder-Rodríguez,Deguang Liang,Xuejun Jiang,Frank A. Sinicrope
标识
DOI:10.1053/j.gastro.2024.01.051
摘要
Ferroptosis is a form of nonapoptotic cell death that involves iron-dependent phospholipid peroxidation induced by accumulation of reactive oxygen species, and results in plasma membrane damage and the release of damage-associated molecular patterns. Ferroptosis has been implicated in aging and immunity, as well as disease states including intestinal and liver conditions and cancer. To date, several ferroptosis-associated genes and pathways have been implicated in liver disease. Although ferroptotic cell death is associated with dysfunction of the intestinal epithelium, the underlying molecular basis is poorly understood. As the mechanisms regulating ferroptosis become further elucidated, there is clear potential to use ferroptosis to achieve therapeutic benefit.
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