化学
光催化
产量(工程)
脱羧
肟
组合化学
催化作用
有机化学
材料科学
冶金
作者
Lijing Li,Wei Yi,Yulian Zhao,Yang Gao,Xiao‐Qiang Hu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-01-26
卷期号:26 (5): 1110-1115
被引量:8
标识
DOI:10.1021/acs.orglett.3c04395
摘要
Despite the significant success of decarboxylative radical reactions, the catalytic systems vary considerably upon different radical acceptors, requiring renewed case-by-case reaction optimization. Herein, we developed an iron catalytic condition that enables the highly efficient decarboxylation of various carboxylic acids for a range of radical transformations. This operationally simple protocol was amenable to a wide array of radical acceptors, delivering structurally diverse oxime ethers, alkenylation, alkynylation, thiolation, and amidation products in useful to excellent yields (>40 examples, up to 95% yield).
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