作者
Émilie Crouchet,Mayssa Dachraoui,Frank Jühling,Natascha Roehlen,Marine Oudot,Sarah Durand,Clara Ponsolles,Cloé Gadenne,Laura Heydmann,Julien Moehlin,Romain Martin,Nicolas Brignon,Fabio Del Zompo,Yuji Teraoka,Hiroshi Aikata,Hiromi Abe‐Chayama,Kazuaki Chayama,Antonio Saviano,Danijela Heide,Mihaela Onea,Lucas L. Geyer,Thibaut Wolf,Emanuele Felli,Patrick Pessaux,Mathias Heikenwälder,Pierre Chambon,Catherine Schuster,Joachim Lupberger,Atish Mukherji,Thomas F. Baumert
摘要
Liver fibrosis is the major driver of hepatocellular carcinoma and liver disease-related death. Approved antifibrotic therapies are absent and compounds in development have limited efficacy. Increased TGF-β signaling drives collagen deposition by hepatic stellate cells (HSCs)/myofibroblasts. Here, we aimed to dissect the role of the circadian clock (CC) in controlling TGF-β signaling and liver fibrosis.