Electrochemically Promoted Skeleton Transformation of 2,1‐Benzisoxazoles to Alkyl Sulfones

Abstract. This study developed an electrochemically promoted skeleton transformation reaction of 2,1‐benzisoxazoles to synthesize alkyl sulfones. The synthesis of alkyl sulfone products in 68%‐93% yields by using 2,1‐benzisoxazole and sulfonate as substrates, and acetonitrile and water were employed as solvents. Mechanism study shows that this reaction work involving the ring opening, the removal of the oxygen atom of 2,1‐benzisoxazoles, and the formation of C(sp3)‐sulfonylation under electrochemical conditions.