Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion

光肩星天牛 氯硝柳胺 杀螺剂 精油 曼氏血吸虫 生物 血吸虫病 生物指节 毒理 传统医学 吡喹酮 化学 食品科学 医学 蠕虫 蜗牛 生态学 动物
作者
Francisco Paiva Machado,Diogo Folly,Ricardo Esteves,Bettina Monika Ruppelt,Vitoria Mirelly Torres Silva,Ana Paula dos Santos Matos,José Augusto Albuquerque dos Santos,Leonardo da Silva Rangel,Marcelo Guerra Santos,Natalia Lidmar von Ranke,Carlos Rangel Rodrigues,Eduardo Ricci‐Júnior,Leandro Rocha,Robson Xavier Faria
出处
期刊:Molecules [Multidisciplinary Digital Publishing Institute]
卷期号:28 (16): 5944-5944
标识
DOI:10.3390/molecules28165944
摘要

Schistosomiasis is a tropical disease transmitted in an aqueous environment by cercariae from the Schistosoma genus. This disease affects 200 million people living in risk areas around the world. The control of schistosomiasis is realized by chemotherapy, wastewater sanitation, health education, and mollusk control using molluscicidal agents. This work evaluates the effects of a nanoemulsion containing essential oil from Myrciaria floribunda leaves as a molluscicidal and cercaricidal agent against Biomphalaria glabrata mollusks and Schistosoma mansoni cercariae. The Myrciaria floribunda essential oil from leaves showed nerolidol, β-selinene, 1,8 cineol, and zonarene as major constituents. The formulation study suggested the F3 formulation as the most promising nanoemulsion with polysorbate 20 and sorbitan monooleate 80 (4:1) with 5% (w/w) essential oil as it showed a smaller droplet size of approximately 100 nm with a PDI lower than 0.3 and prominent bluish reflection. Furthermore, this nanoemulsion showed stability after 200 days under refrigeration. The Myrciaria floribunda nanoemulsion showed LC50 values of 48.11 µg/mL, 29.66 µg/mL, and 47.02 µg/mL in Biomphalaria glabrata embryos, juveniles, and adult mollusks, respectively, after 48 h and 83.88 µg/mL for Schistosoma mansoni cercariae after 2 h. In addition, a survival of 80% was observed in Danio rerio, and the in silico toxicity assay showed lower overall human toxicity potential to the major compounds in the essential oil compared to the reference molluscicide niclosamide. These results suggest that the nanoemulsion of Myrciaria floribunda leaves may be a promising alternative for schistosomiasis control.
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