斑马鱼
干细胞
银屑病
计算生物学
生物
细胞生物学
免疫学
生物化学
基因
作者
Babak Arjmand,Sepideh Alavi-Moghadam,Shayesteh Kokabi-Hamidpour,Rasta Arjmand,Mostafa Rezaei‐Tavirani,Bagher Larijani
出处
期刊:Methods in molecular biology
日期:2023-01-01
标识
DOI:10.1007/7651_2023_505
摘要
Psoriasis is a chronic, inflammatory, autoimmune disease with systemic symptoms including seborrheic psoriasis, pustular lesions, plaque lesions, intestinal eruptions, and sometimes arthritis. Moreover, most of the psoriatic subjects report life challenges due to the condition, impacting social activities and daily tasks. Generally, psoriasis treatment options depend on the severity, coexisting conditions, and medical availability. Although psoriasis therapies reduce symptoms and appearance, still it is not curable. Hereupon, searching for optimal therapeutic options continues. Accordingly, stem cell therapy is considered an advanced psoriasis treatment. Subsequently, stem cell therapies' efficacy is uncertain yet. Therefore, further studies are needed. In this context, preclinical studies such as animal experiments are essential for evaluation of treatment modalities. Herein, zebrafish offer advantages in testing treatments and biomedical research applications compared to other vertebrate models. Further, zebrafish skin shares similarities with human skin, making it suitable for studying inflammatory disorders. Hence, the authors discuss the zebrafish psoriasis development method for evaluating the stem cell therapeutic influence.
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