生物
汉坦病毒
干扰素
MDA5型
先天免疫系统
信号转导
钻机-I
病毒学
基因
免疫系统
细胞生物学
病毒
遗传学
汉坦病毒
核糖核酸
RNA干扰
作者
Yinghua Zhao,Lihe Che,Mingming Pan,Yuan Huang,Shu Fang,Mengmeng Wang,Liyan Sui,Zedong Wang,Fang Du,Zhijun Hou,Quan Liu
出处
期刊:Virology
[Elsevier]
日期:2023-11-22
卷期号:589: 109942-109942
标识
DOI:10.1016/j.virol.2023.109942
摘要
Hantaan virus (HTNV) is responsible for hemorrhagic fever with renal syndrome (HFRS), primarily due to its ability to inhibit host innate immune responses, such as type I interferon (IFN-I). In this study, we conducted a transcriptome analysis to identify host factors regulated by HTNV nucleocapsid protein (NP) and glycoprotein. Our findings demonstrate that NP and Gc proteins inhibit host IFN-I production by manipulating the retinoic acid-induced gene I (RIG-I)-like receptor (RLR) pathways. Further analysis reveals that HTNV NP and Gc proteins target upstream molecules of MAVS, such as RIG-I and MDA-5, with Gc exhibiting stronger inhibition of IFN-I responses than NP. Mechanistically, NP and Gc proteins interact with tripartite motif protein 25 (TRIM25) to competitively inhibit its interaction with RIG-I/MDA5, suppressing RLR signaling pathways. Our study unveils a cross-talk between HTNV NP/Gc proteins and host immune response, providing valuable insights into the pathogenic mechanism of HTNV.
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