Angiopoietin 2 and hsCRP are associated with pulmonary hemodynamics and long-term mortality respectively in CTEPH—Results from a prospective discovery and validation biomarker study

医学 血管生成素 血栓 内科学 心脏病学 生物标志物 血管生成 胃肠病学 内皮细胞活化 肺动脉高压 内皮功能障碍 比例危险模型 肺栓塞 慢性血栓栓塞性肺高压 血流动力学 炎症 血管内皮生长因子 化学 血管内皮生长因子受体 生物化学
作者
Charaka Hadinnapola,Mark Southwood,Jules Hernández‐Sánchez,Katherine Bunclark,Michael Newnham,Emilia M. Swietlik,John Cannon,Stephen Preston,Karen Sheares,Dolores Taboada,Nicholas Screaton,David P. Jenkins,Nicholas W. Morrell,Mark Toshner,Joanna Pepke‐Żaba
出处
期刊:Journal of Heart and Lung Transplantation [Elsevier BV]
卷期号:42 (3): 398-405 被引量:9
标识
DOI:10.1016/j.healun.2022.08.021
摘要

Chronic thromboembolic pulmonary hypertension (CTEPH) is an underdiagnosed disease of uncertain etiology. Altered endothelial homeostasis, defective angiogenesis and inflammation are implicated. Angiopoietin 2 (Ang2) impairs acute thrombus resolution and is associated with vasculopathy in idiopathic pulmonary arterial hypertension.We assessed circulating proteins associated with these processes in serum from patients with CTEPH (n = 71) before and after pulmonary endarterectomy (PEA), chronic thromboembolic pulmonary disease without pulmonary hypertension (CTEPD, n = 9) and healthy controls (n = 20) using Luminex multiplex arrays. Comparisons between groups were made using multivariable rank regression models. Ang2 and high-sensitivity C-reactive protein (hsCRP) were measured in a larger validation dataset (CTEPH = 277, CTEPD = 26). Cox proportional hazards models were used to identify markers predictive of survival.In CTEPH patients, Ang2, interleukin (IL) 8, tumor necrosis factor α, and hsCRP were elevated compared to controls, while vascular endothelial growth factor (VEGF) c was lower (p < 0.05). Ang2 fell post-PEA (p < 0.05) and was associated with both pre- and post-PEA pulmonary hemodynamic variables and functional assessments (p < 0.05). In the validation dataset, Ang2 was significantly higher in CTEPH compared to CTEPD. Pre-operative hsCRP was an independent predictor of mortality.We hypothesize that CTEPH patients have significant distal micro-vasculopathy and consequently high circulating Ang2. Patients with CTEPD without pulmonary hypertension have no discernible distal micro-vasculopathy and therefore have low circulating Ang2. This suggests Ang2 may be critical to CTEPH disease pathogenesis (impaired thrombus organization and disease severity).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
chen完成签到 ,获得积分10
刚刚
彩色纹发布了新的文献求助30
刚刚
1秒前
王一一发布了新的文献求助10
1秒前
1秒前
无限莫言发布了新的文献求助10
2秒前
pluto应助水水采纳,获得10
2秒前
木木完成签到,获得积分10
2秒前
我想@科研发布了新的文献求助10
3秒前
赵锐完成签到,获得积分10
3秒前
lqllll发布了新的文献求助30
3秒前
佳佳完成签到,获得积分10
3秒前
酷波er应助酷酷巧蟹采纳,获得10
3秒前
小郑完成签到,获得积分10
4秒前
4秒前
小蘑菇应助荷兰香猪采纳,获得10
4秒前
华仔应助木子采纳,获得10
5秒前
5秒前
明亮元柏发布了新的文献求助10
5秒前
5秒前
呵呵哒完成签到,获得积分10
5秒前
5秒前
6秒前
充电宝应助激动的小海豚采纳,获得10
6秒前
Thhhhm完成签到,获得积分10
6秒前
6秒前
6秒前
打打应助xy采纳,获得10
6秒前
淡淡的小蚂蚁完成签到,获得积分20
7秒前
8秒前
8秒前
大胆的颜演完成签到,获得积分10
8秒前
9秒前
9秒前
9秒前
斯文明杰发布了新的文献求助10
10秒前
Zq完成签到,获得积分10
10秒前
到底是谁还在做牛马完成签到,获得积分10
10秒前
12秒前
12秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3971216
求助须知:如何正确求助?哪些是违规求助? 3515911
关于积分的说明 11180016
捐赠科研通 3251003
什么是DOI,文献DOI怎么找? 1795626
邀请新用户注册赠送积分活动 875937
科研通“疑难数据库(出版商)”最低求助积分说明 805207