Were examined clinical and laboratory examined 138 patients: 93 people with gastroesophageal reflux disease (GERD) in whose mouth there were changes in the periodontal tissues, and 45 people without a concomitant GERD with help of clinical and laboratory methods. All patients were conducted to clinical examination of the oral cavity with the establishment of periodontal status on the basis of Florida Proub system and evaluation index. During the study was analyzed the major dental complaints as extraesophageal symptoms in patients with reflux esophagitis, as well as evaluation of the inflammatory process in periodontal tissues, depending on the stage of GERD.