促炎细胞因子
医学
银屑病性关节炎
类风湿性关节炎
肿瘤坏死因子α
滑液
关节炎
骨关节炎
银屑病
免疫学
滑膜
白细胞介素
炎性关节炎
内科学
细胞因子
炎症
病理
替代医学
作者
G Partsch,G Steiner,B.F. Leeb,Attila Dunky,H Bröll,J S Smolen
出处
期刊:PubMed
日期:1997-03-01
卷期号:24 (3): 518-23
被引量:291
摘要
To investigate the potential role of cytokines in psoriatic arthritis (PsA) by assessing the profiles of the proinflammatory cytokines in synovial fluid (SF) of PsA in comparison with rheumatoid arthritis (RA) and osteoarthritis (OA).Levels of tumor necrosis factor-alpha (TNF-alpha), interleukin 1 (IL-1), IL-6, and IL-8 were measured in SF using ELISA.Levels of TNF-alpha, IL-1beta, and IL-8 were significantly higher in PsA SF than in OA SF, although lower than in RA SF. No difference was detected in the IL-6 levels between PsA and RA SF, both of which were much higher than in OA SF.The pattern of expression of proinflammatory cytokines seen in PsA is similar to that in RA. Since PsA is also a destructive arthropathy, cytokines, in particular TNF-alpha and IL-1, may be principle factors in joint destruction.
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