抗体依赖性细胞介导的细胞毒性
单克隆抗体
CD16
效应器
细胞毒性
抗体
体外
化学
机制(生物学)
流式细胞术
免疫学
生物
免疫系统
生物化学
CD3型
物理
量子力学
CD8型
作者
Aaron S. Miller,Max L. Tejada,Hélène Gazzano-Santoro
出处
期刊:Methods in molecular biology
日期:2014-01-01
卷期号:: 59-65
被引量:3
标识
DOI:10.1007/978-1-4939-0326-9_5
摘要
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a relevant characteristic to measure for a number of therapeutic monoclonal antibodies (mAbs) under development. ADCC is a mechanism by which antibody-opsonized, infected, or cancerous cells are destroyed by FcγRIII (CD16)-expressing effector cells. Here we describe three methods that can be used to quantify the ADCC activity of mAbs by measuring distinct aspects of the ADCC mechanism.
科研通智能强力驱动
Strongly Powered by AbleSci AI