载脂蛋白E
亚甲基四氢叶酸还原酶
维生素B12
同型半胱氨酸
基因分型
内科学
等位基因
阿尔茨海默病
风险因素
疾病
医学
基因型
内分泌学
生物
遗传学
基因
作者
Maria Styczyńska,Joanna B. Strosznajder,Dorota Religa,Małgorzata Chodakowska-Żebrowska,Anna Pfeffer,Tomasz Gabrylewicz,Grzegorz A. Czapski,Małgorzata Kobryś,Gytis Karčiauskas,Maria Barcikowska
出处
期刊:PubMed
日期:2008-01-01
卷期号:46 (4): 249-54
被引量:21
摘要
The only well confirmed genetic risk factor for sporadic Alzheimer's disease (AD) is the possession of apolipoprotein E (APOE) epsilon4 allele. As it contributes to 40-70% of AD cases, a large proportion of genetic variance may be determined by additional loci. Our aim was to estimate how reported genetic factors (APOE, NOS3, MTHFR) interact to increase the risk for AD and combine them with environmental factors (homocysteine, vitamin B12, cholesterol). Genotyping was performed in 154 AD patients and 176 healthy controls. Levels of homocysteine, vitamin B12 and cholesterol were assessed in subgroups of 100 AD patients and 100 controls. We found a difference in APOE epsilon4 and NOS3 G/G distribution between groups (p<0.005). Plasma total homocysteine was increased and vitamin B12 decreased in AD patients (p<0.001). The influence of APOE epsilon4 and NOS3 G alleles on the risk of AD was independent of homocysteine, vitamin B12 levels and MTHFR status.
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