Effect of dietary fiber on symptoms and rectosigmoid motility in patients with irritable bowel syndrome

医学 安慰剂 肠易激综合征 直肠乙状结肠 内科学 餐后 膳食纤维 胃肠病学 直肠 食品科学 病理 化学 替代医学 胰岛素
作者
Ian J. Cook,E. Jan Irvine,Dugal Campbell,Susan Shannon,S. Narasimha Reddy,Stephen M. Collins
出处
期刊:Gastroenterology [Elsevier]
卷期号:98 (1): 66-72 被引量:93
标识
DOI:10.1016/0016-5085(90)91292-e
摘要

The aims of this study were to determine (a) whether dietary fiber supplements modify symptoms in patients with irritable bowel syndrome, (b) the effect of fiber on rectosigmoid pressures, and (c) the relationship, if any, between rectosigmoid pressure and symptoms. Fourteen patients entered and 9 completed a double-blind, controlled, cross-over study of 7 mo duration. The mean age was 26 yr (range, 18-37). Patients received 4 cookies daily containing 20 mg corn fiber or placebo. Symptoms and compliance were evaluated monthly. Rectosigmoid pressures and dietary intake were evaluated at the outset and completion of each study arm. Symptoms improved during both fiber and placebo treatments. Those symptoms demonstrating significant improvement with time were pain severity, stool frequency, stool consistency (p = 0.001), number of additional gastrointestinal symptoms present (p = 0.02), and total symptom score (p less than 0.001). Rectosigmoid pressures were not significantly altered by fiber or placebo. Fasting pressures at the distal recording site tended to correlate with pain severity (r = 0.6; p = 0.06). It was concluded that (a) corn fiber and placebo were both effective in alleviating symptoms, (b) there was a correlation between symptom severity and fasting rectosigmoid pressure, and (c) there was a trend toward reduction in fasting and postprandial rectosigmoid pressures after fiber therapy.
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