阻塞性睡眠呼吸暂停
自噬
缺氧(环境)
发病机制
医学
生物标志物
间歇性缺氧
睡眠呼吸暂停
效应器
内科学
心脏病学
生物信息学
免疫学
生物
化学
细胞凋亡
有机化学
氧气
生物化学
作者
F. Schlemmer,M. Zysman,Bruno Ribeiro Baptista,Étienne Audureau,Ala Noroc,Audrey Ridoux,Geneviève Dérumeaux,Serge Adnot,Bernard Maître,Philippe Le Corvoisier,Sophie Lanone,Jorge Boczkowski,Laurent Boyer
标识
DOI:10.1016/j.sleep.2021.03.017
摘要
Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults. Adaptative pathways induced by hypoxia could implicate autophagic processes and Beclin-1, one of the first mammalian autophagy effectors. Thus, activation of autophagy could protect against cardiovascular events in patients with OSA and could be considered as biomarker of a better prognosis.
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