5-Aminolevulinic acid for enhanced surgical visualization of high-grade gliomas: a prospective, multicenter study

PPIX fluorescence, as judged by the surgeon, has a high sensitivity and PPV for HGG. 5-ALA was well tolerated in terms of drug-related adverse events, and its application by trained surgeons in FGS for HGGs was not associated with any excess neurological morbidity.