原花青素
人类健康
健康福利
聚合
化学
抗氧化剂
聚合度
生物化学
单体
多酚
食品科学
聚合物
传统医学
有机化学
医学
环境卫生
作者
Haixia Yang,Xingxia Tuo,Lingbo Wang,Rosa Tundis,Marı́a P. Portillo,Jesús Simal-Gándara,Yan Yu,Liang Zou,Jianbo Xiao,Jianjun Deng
标识
DOI:10.1016/j.tifs.2021.02.063
摘要
Procyanidins, commonly found in plant natural sources, are polymerized forms of flavanols, which are a subclass of flavonoids. They have been reported to exhibit broad benefits to human health and used in the prevention of cancers, cardiovascular diseases, diabetes, etc. Bioactivities of procyanidins depend on many factors including the structures of procyanidins. Differences in composition of the monomers and degree of polymerization (DP) contribute to the variation in procyanidins. The basic structures and natural sources of procyanidins have been summarized in detail. Importantly, the structure-activity relationships of procyanidins, especially the relationship between degrees of polymerization and their antioxidant, anticancer, antidiabetic, anti-obesity, and cardioprotective effects as well as their potential mechanisms have been reviewed in detail. Additionally, current challenges in the studies of procyanidins have been discussed. Procyanidins are structurally diverse compounds and can be classified as monomeric, oligomeric, or polymeric variants depending on the DP, which plays a role in manifesting various effects that are associated with human health. The diversity and complexity of these chemical compounds and the difficulties encountered in the isolation of plant procyanidins continue to be major challenges. A better understanding of this information may promote the use of procyanidins in improving human health.
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