膀胱癌
膀胱切除术
内科学
肿瘤科
医学
比例危险模型
队列
阶段(地层学)
基因表达
淋巴血管侵犯
生存分析
癌症
癌症研究
基因
生物
转移
古生物学
生物化学
作者
Katja Nitschke,Thomas Worst,Sophie Madeleine von Rhade,Blerta Thaqi,Manuel Neuberger,Frederik Wessels,Cleo‐Aron Weis,Štefan Porubský,Timo Gaiser,Maximilian C. Kriegmair,Jost von Hardenberg,Marc Weidenbusch,Philipp Erben,Philipp Nuhn
标识
DOI:10.1016/j.urolonc.2021.05.010
摘要
The cell surface interleukin 22 (IL-22) receptor complex is mainly expressed in epithelial and tissue cells like pancreatitis cells. Recent studies described that IL-22R was overexpressed in malignant diseases and was associated with a poor overall survival (OS). The role of IL-22RA1 gene expression in muscle invasive bladder cancer (MIBC) has not been investigated, yet.The aim of this study was to analyze the role of IL-22RA1 gene expression in patients with MIBC.In a cohort of 114 patients with MIBC who underwent radical cystectomy, IL-22RA1 gene expression was analyzed with qRT-PCR and correlated with clinical parameters. Furthermore, Kaplan-Meier and Cox regression analysis were performed. For validation, an in silico dataset (TCGA 2017, n=407) was reanalyzed.IL-22RA1 gene expression was independent of clinicopathological parameters like age (P=0.2681), T stage (P=0.2130), nodal status (P=0.3238) and lymph vascular invasion (LVI, P=0.5860) in patients with MIBC. A high expression of IL-22RA1 was associated with a shorter OS (P=0.0040) and disease-specific survival (P=0.0385). Furthermore, a shorter disease-free survival (DFS) was also associated with a high expression of IL-22RA1 (P=0.0102). In the multivariable analysis, IL-22RA1 expression was an independent prognostic predictors regarding OS (P=0.0096, HR=0.48). In the TCGA cohort, IL-22RA1 expression was independent regarding to OS and DFS.A high IL-22RA1 gene expression was associated with worse outcome. Furthermore, IL-22RA1 represented an independent predictor regarding OS in our cohort and therefore might be used for risk stratification in patients with MIBC.
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