小檗碱
神经保护
神经炎症
医学
自噬
药理学
生物碱
神经科学
程序性细胞死亡
氧化应激
生物
疾病
细胞凋亡
病理
生物化学
内分泌学
植物
作者
Dahua Fan,Liping Liu,Zhengzhi Wu,Meiqun Cao
出处
期刊:Current Neuropharmacology
[Bentham Science]
日期:2018-04-20
卷期号:17 (6): 563-579
被引量:56
标识
DOI:10.2174/1570159x16666180419141613
摘要
Neurodegenerative diseases are among the most serious health problems affecting millions of people worldwide. Such diseases are characterized by a progressive degeneration and / or death of neurons in the central nervous system. Currently, there are no therapeutic approaches to cure or even halt the progression of neurodegenerative diseases. During the last two decades, much attention has been paid to the neuroprotective and anti-neurodegenerative activities of compounds isolated from natural products with high efficacy and low toxicity. Accumulating evidence indicates that berberine, an isoquinoline alkaloid isolated from traditional Chinese medicinal herbs, may act as a promising anti-neurodegenerative agent by inhibiting the activity of the most important pathogenic enzymes, ameliorating intracellular oxidative stress, attenuating neuroinflammation, triggering autophagy and protecting neurons against apoptotic cell death. This review attempts to summarize the current state of knowledge regarding the therapeutic potential of berberine against neurodegenerative diseases, with a focus on the molecular mechanisms that underlie its effects on Alzheimer's, Parkinson's and Huntington's diseases.
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