纳米医学
纳米载体
联合疗法
药理学
核酸
药品
药物输送
医学
化学
纳米技术
材料科学
生物化学
纳米颗粒
有机化学
作者
Wei Huang,Liqing Chen,Lin Kang,Mingji Jin,Sun Park,Xin Xin,Zhonggao Gao,You Han Bae
标识
DOI:10.1016/j.addr.2017.06.004
摘要
Anticancer therapy has always been a vital challenge for the development of nanomedicine. Repeated single therapeutic agent may lead to undesirable and severe side effects, unbearable toxicity and multidrug resistance due to complex nature of tumor. Nanomedicine-based combination anticancer therapy can synergistically improve antitumor outcomes through multiple-target therapy, decreasing the dose of each therapeutic agent and reducing side effects. There are versatile combinational anticancer strategies such as chemotherapeutic combination, nucleic acid-based co-delivery, intrinsic sensitive and extrinsic stimulus combinational patterns. Based on these combination strategies, various nanocarriers and drug delivery systems were engineered to carry out the efficient co-delivery of combined therapeutic agents for combination anticancer therapy. This review focused on illustrating nanomedicine-based combination anticancer therapy between nucleic acids and small-molecular drugs for synergistically improving anticancer efficacy.
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