免疫突触
T细胞受体
内体
细胞生物学
CD3型
主要组织相容性复合体
免疫系统
T细胞
突触
化学
细胞内
生物
免疫学
CD8型
神经科学
作者
Laura Patrussi,Cosima T. Baldari
出处
期刊:Methods in molecular biology
日期:2017-01-01
卷期号:: 143-155
被引量:5
标识
DOI:10.1007/978-1-4939-6881-7_10
摘要
Engagement of the T cell antigen receptor (TCR) by specific ligand bound to the major histocompatibility complex is the primary event that leads to the assembly of the immune synapse (IS). Central to this process is TCR clustering at the T cell-APC contact, which is achieved with the contribution of an endosomal pool that is delivered to the IS by polarized recycling. As the TCR recycling process has not been fully elucidated, we developed methods suitable to quantitate recycling to the plasma membrane of TCR/CD3 complexes that have been engaged at the cell surface and track their traffic through the intracellular vesicular compartments toward the IS.
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