脚手架
抗菌活性
活性氧
灭菌(经济)
材料科学
软骨发生
谷胱甘肽
化学
纳米技术
生物物理学
细菌
生物医学工程
医学
生物
生物化学
细胞
经济
酶
外汇市场
货币经济学
遗传学
外汇
作者
Guowen Qian,Lemin Zhang,Shuai Yang,Xiongting Wu,Zhikui Zeng,Shuping Peng,Cijun Shuai
标识
DOI:10.1016/j.apsusc.2022.156108
摘要
There is an increasingly growing demand for rapid and safe sterilization strategies to overcome implantation-associated infection. Herein, a NIR light-triggered antimicrobial heterojunction of CuFe2O4-MXene was constructed by in-situ growing CuFe2O4 on Ti3C2 MXene, then was homogeneously incorporated into poly (L-lactic acid) and fabricated into tracheal scaffold by selective laser technology. The tracheal scaffolds with the heterojunction not only generated hyperthermia and exogenous reactive oxygen species (ROS) under NIR light irradiation, but also depleted glutathione (GSH) in bacteria and produce endogenous ROS via Fenton(−like) reaction, thus achieving strong and persistent antibacterial cascade effect. They killed 96.49% of S. aureus and 95.33% of P. aeruginosa after NIR light irradiating for 15 min. Moreover, the tracheal scaffold with the heterojunction had excellent cytocompatibility and chondrogenic-promoting ability. This work designed the tracheal scaffold with effective antibacterial ability and cartilage regeneration function, which will bring a new dawn for the patients with tracheal injury.
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