转录组
焦虑
神经科学
社会压力
扣带回前部
情绪障碍
慢性应激
生物信息学
心理学
生物
精神科
医学
遗传学
基因表达
基因
认知
作者
Hiromichi Inaba,Haiyan Li,Ayako Kawatake-Kuno,Ken‐ichi Dewa,Jun Nagai,Naoya Oishi,Toshiya Murai,Shinichi Uchida
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-04-07
卷期号:9 (14)
被引量:9
标识
DOI:10.1126/sciadv.ade5397
摘要
Chronic stress increases the risk of developing psychiatric disorders, including mood and anxiety disorders. Although behavioral responses to repeated stress vary across individuals, the underlying mechanisms remain unclear. Here, we perform a genome-wide transcriptome analysis of an animal model of depression and patients with clinical depression and report that dysfunction of the Fos-mediated transcription network in the anterior cingulate cortex (ACC) confers a stress-induced social interaction deficit. Critically, CRISPR-Cas9-mediated ACC Fos knockdown causes social interaction deficits under stressful situation. Moreover, two classical second messenger pathways, calcium and cyclic AMP, in the ACC during stress differentially modulate Fos expression and regulate stress-induced changes in social behaviors. Our findings highlight a behaviorally relevant mechanism for the regulation of calcium- and cAMP-mediated Fos expression that has potential as a therapeutic target for psychiatric disorders related to stressful environments.
科研通智能强力驱动
Strongly Powered by AbleSci AI