腺癌
基础(线性代数)
肺
计算生物学
病理
化学
生物
医学
内科学
数学
癌症
几何学
作者
Liping Zha,James P. Sluka,James P. Sluka,James P. Sluka,James P. Sluka
出处
期刊:iScience
[Elsevier]
日期:2024-05-01
卷期号:27 (5): 109742-109742
标识
DOI:10.1016/j.isci.2024.109742
摘要
Lung adenocarcinoma (LUAD), which accounts for a large proportion of lung cancers, is divided into five major subtypes based on histologic characteristics. The clinical characteristics, prognosis, and responses to treatments vary among subtypes. Here, we demonstrate that the variations of cell-cell contact energy result in the LUAD subtype-specific morphogenesis. We reproduced the morphologies of the papillary LUAD subtypes with the cellular Potts Model (CPM). Simulations and experimental validations revealed modifications of cell-cell contact energy changed the morphology from a papillary-like structure to micropapillary or solid subtype-like structures. Remarkably, differential gene expression analysis revealed subtype-specific expressions of genes relating to cell adhesion. Knockdown experiments of the micropapillary upregulated
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