Phthalate and DINCH exposure and ovarian reserve markers among women seeking infertility care

邻苯二甲酸盐 卵巢储备 不育 医学 妇科 环境卫生 产科 生理学 生物 怀孕 化学 遗传学 有机化学
作者
Yangqian Jiang,Yiqun Xu,Shuxin Xiao,Xianxian Zhu,Hong Lv,Lu Zang,Shuifang Lei,Xin Xu,Bo Xu,Xiumei Han,Jin Zhu,Jiangbo Du,Hongxia Ma,Zhibin Hu,Xiufeng Ling,Jiayin Dai,Yuan Lin
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:927: 172185-172185 被引量:1
标识
DOI:10.1016/j.scitotenv.2024.172185
摘要

Phthalate exposure can adversely impact ovarian reserve, yet investigation on the influence of its alternative substance, the non-phthalate plasticizer diisononyl-cyclohexane-1,2-dicarboxylate (DINCH), on ovarian reserve is very sparce. We aimed to investigate the associations of phthalate and DINCH exposure as well as their combined mixture with ovarian reserve. This present study included 657 women seeking infertility care in Jiangsu, China (2015–2018). Urine samples during enrollment prior to infertility treatment were analyzed using high-performance liquid chromatography-isotope dilution tandem mass spectrometry (UPLC-MS/MS) to quantify 17 phthalate metabolites and 3 DINCH metabolites. Multivariate linear regression models, Poisson regression models and weighted quantile sum (WQS) regression were performed to access the associations of 17 urinary phthalate metabolites and 3 DINCH metabolites with ovarian reserve markers, including antral follicle count (AFC), anti-Mullerian hormone (AMH), and follicle-stimulating hormone (FSH). We found that the most conventional phthalates metabolites (DMP, DnBP, DiBP, DBP and DEHP) were inversely associated with AFC, and the DINCH metabolites were positively associated with serum FSH levels. The WQS index of phthalate and DINCH mixtures was inversely associated with AFC (% change = −8.56, 95 % CI: −12.63, −4.31) and positively associated with FSH levels (% change =7.71, 95 % CI: 0.21, 15.78). Our findings suggest that exposure to environmental levels of phthalate and DINCH mixtures is inversely associated with ovarian reserve.
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