荧光原位杂交
多发性骨髓瘤
融合基因
癌症研究
费城染色体
淋巴瘤
断点群集区域
细胞遗传学
染色体易位
医学
急性淋巴细胞白血病
免疫分型
肿瘤科
白血病
内科学
免疫学
染色体
生物
淋巴细胞白血病
基因
流式细胞术
遗传学
受体
作者
Kurt W. Miller,Jonathan Webster,Philip Imus,Candice Ament,Melanie Hardy,Ying Zou
标识
DOI:10.1016/j.cancergen.2023.03.005
摘要
Secondary hematologic malignancies, such as B-cell acute lymphoblastic leukemia/lymphoma (B-ALL), have been reported following multiple myeloma. Tyrosine kinase inhibitors have improved clinical outcomes of patients with Philadelphia-positive (Ph+) B-ALL. Therefore, recognition of the Ph chromosome in B-ALL patients is important for both prognosis and therapies. We present a case of a secondary Ph+ B-ALL following multiple myeloma that highlights a BCR::ABL1 fusion by a gene fusion assay to reveal a cryptic Ph chromosome, which may otherwise be missed by conventional cytogenetics and typical interphase fluorescence in situ hybridization.
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