三萜
双环分子
立体化学
糖苷
角鲨烯
化学
戒指(化学)
绝对构型
有机化学
医学
病理
替代医学
作者
Kang Chen,Jianshuang Zhou,Baoqing Dun,Wenfei Zhang,Chen Wang,Linan Xie,Yuquan Xu
标识
DOI:10.1021/acs.jnatprod.3c00243
摘要
Six new squalene derived polyether glycosides, onygenaleosides A–F (1–6), that possess a 6/5 bicyclic fused ring skeleton were isolated from the cultures of Onygenales sp. YX1425, along with two known analogues (7 and 8). The planar structures of the new compounds were elucidated based on analysis of NMR and MS spectroscopy data, and the absolute configuration of 1 was determined by the advanced Mosher method and quantum chemical calculations. Compound 2 was active against Spodoptera frugiperda with an LC50 value of 193.4 ± 1.1 μg/mL.
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