Do we all need to learn aortic valve repair the HAART way?

We read with great interest the recent article by Lancaster and colleagues1Lancaster T.S. Romano J.C. Si M.S. Ohye R.G. Aortic valve repair using geometric ring annuloplasty in pediatric and congenital heart disease patients.J Thorac Cardiovasc Surg. 2023; 166: 294-303Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar describing hemispherical aortic annuloplasty reconstructive technology (HAART) in adolescents, which requires implantation of a rigid ring inside the aorta (Figure 1, A). A few immediate questions come to mind. Is implantation of an internal ring necessary if efficient and durable stabilization could be achieved with other annuloplasty techniques? Would the expected endothelization of the ring induce fibrosis in the high-shear-stress subaortic area? Would this, in turn, create an iatrogenic subaortic membrane and induce the spread of the fibrosis into the base of the cusps? Would this ring influence the valve function long term? These questions remain to be answered and are of great importance, especially because durable stabilization techniques with proven long-term excellent results already exist. With increasing experience in aortic valve repair, the need for aortic root stabilization has become evident. An annuloplasty2Aicher D. Schneider U. Schmied W. Kunihara T. Tochii M. Schafers H.J. Early results with annular support in reconstruction of the bicuspid aortic valve.J Thorac Cardiovasc Surg. 2013; 145: S30-S34Abstract Full Text Full Text PDF PubMed Scopus (108) Google Scholar, 3Schneider U. Aicher D. Miura Y. Schafers H.J. Suture annuloplasty in aortic valve repair.Ann Thorac Surg. 2016; 101: 783-785Abstract Full Text Full Text PDF PubMed Scopus (94) Google Scholar, 4Schneider U. Hofmann C. Schöpe J. Niewald A.K. Giebels C. Karliova I. et al.Long-term results of differentiated anatomic reconstruction of bicuspid aortic valves.JAMA Cardiol. 2020; 5: 1366-1373Crossref PubMed Scopus (52) Google Scholar, 5Lansac E. Di Centa I. Sleilaty G. Crozat E.A. Bouchot O. Hacini R. et al.An aortic ring: from physiologic reconstruction of the root to a standardized approach for aortic valve repair.J Thorac Cardiovasc Surg. 2010; 140 (discussion S45-51): S28-S35Abstract Full Text Full Text PDF PubMed Scopus (76) Google Scholar has been previously applied with very good long-term results using either suture (Figure 1, B) or an external ring (Figure 1, C). Such technique has been proven to provide durable and reproducible long-term results.4Schneider U. Hofmann C. Schöpe J. Niewald A.K. Giebels C. Karliova I. et al.Long-term results of differentiated anatomic reconstruction of bicuspid aortic valves.JAMA Cardiol. 2020; 5: 1366-1373Crossref PubMed Scopus (52) Google Scholar,5Lansac E. Di Centa I. Sleilaty G. Crozat E.A. Bouchot O. Hacini R. et al.An aortic ring: from physiologic reconstruction of the root to a standardized approach for aortic valve repair.J Thorac Cardiovasc Surg. 2010; 140 (discussion S45-51): S28-S35Abstract Full Text Full Text PDF PubMed Scopus (76) Google Scholar Similar techniques have been applied to stabilize autografts after the Ross operation.6Williams E. El-Hamamsy I. The Ross procedure.Op Tech Thorac Cardiovasc Surg. 2021; 26: 189-209Abstract Full Text Full Text PDF Scopus (7) Google Scholar, 7Konstantinov I.E. Buratto E. Modified root inclusion technique for the Ross procedure in children.Op Tech Thorac Cardiovasc Surg. 2022; 27: 405-413Abstract Full Text Full Text PDF Scopus (4) Google Scholar, 8Buratto E. Skillington P.D. Konstantinov I.E. Autograft stabilization for the Ross procedure in children.Op Tech Thorac Cardiovasc Surg. 2022; 27: 198-205Abstract Full Text Full Text PDF Scopus (5) Google Scholar Although suture annuloplasty is effective in most patients with symmetrical annular dilatation, some patients with asymmetrical dilatation after previous truncal valve surgery or arterial switch operation, particularly with so-called run away sinus,9Fricke T.A. Konstantinov I.E. Buratto E. Brizard C.P. Neo-aortic valve repair and Ross procedure after the arterial switch operation.Op Tech Thorac Cardiovasc Surg. 2021; 26: 277-289Abstract Full Text Full Text PDF Scopus (5) Google Scholar,10Konstantinov I.E. Brizard C.P. Buratto E. Congenital aortic valve repair when the options aren't good: truncus arteriosus and transposition of the great arteries.Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2023; 26: 56-62Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar will require stabilization with an external ring (Figure 1, C). Most importantly, it is the current expectation that with proper stabilization technique the aortic valve repair will last for life and must have a durable long-term result. HAART is an interesting option for aortic valve repair and aortic root stabilization. Previously published articles described substantial reduction in aortic regurgitation and acceptable mean gradients across the aortic valve after HAART implantation at midterm.11Mazzitelli D. Pfeiffer S. Rankin J.S. Fischlein T. Choi Y.H. Wahlers T. et al.A regulated trial of bicuspid aortic valve repair supported by geometric ring annuloplasty.Ann Thorac Surg. 2015; 99: 2010-2016Abstract Full Text Full Text PDF PubMed Scopus (38) Google Scholar,12Drysdale N.D. Andersen N.D. Meza J.M. Lodge A.J. Rankin J.S. Turek J.W. Initial application of a bicuspid aortic annuloplasty ring in pediatric cardiac surgery.Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2020; 23: 29-33Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar The argument that the HAART ring eliminates the need for proximal coronary artery dissection would not hold in patients undergoing valve-sparing root replacement because most of the time the coronary buttons are dissected anyway. Furthermore, this argument is, generally, not strong because in most patients the annulus can be reduced and stabilized with a suture without dissection of the coronary arteries. In contrast to other widely used annuloplasty techniques, HAART necessitates intraluminal placement of the rigid ring and, despite the best effort, may have direct contact with aortic cusps in diastole and cause increased shear stress in the subaortic area in systole. Thus, it appears counterintuitive to place a bulky annuloplasty ring in a subvalvular area and pledgets inside the aorta because such an arrangement appears to be doomed to induce aortic valve fibrosis at the hinge point of each cusp. Would this, in fact, induce aortic valve fibrosis long term? Time will tell. In any rate, there are durable and reproducible alternatives for aortic annulus stabilization without intraluminal rings. The authors reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest. Aortic valve repair using geometric ring annuloplasty in pediatric and congenital heart disease patientsThe Journal of Thoracic and Cardiovascular SurgeryVol. 166Issue 2PreviewExisting replacement options for the aortic valve have significant drawbacks, especially in children. A geometric annuloplasty ring can help to achieve consistently successful aortic valve repair, but only limited experience with use of this device has been reported in pediatric and congenital heart disease patients. Full-Text PDF