催乳素
催乳素细胞
内分泌学
内科学
脂肪变性
脂肪肝
脂肪酸
疾病
化学
医学
生物
生物化学
激素
作者
Xinlu Ji,Hongli Yin,Tianwei Gu,Hao Xu,Fang Da,Kai Wang,Haixiang Sun,Sai Tian,Tianyu Wu,Yuanyuan Nie,Pengzi Zhang,Yan Bi
出处
期刊:Cell Reports
[Elsevier]
日期:2024-07-01
卷期号:43 (7): 114465-114465
标识
DOI:10.1016/j.celrep.2024.114465
摘要
The pituitary is the central endocrine gland with effects on metabolic dysfunction-associated steatotic liver disease (MASLD). However, it is not clear whether the pituitary responds to free fatty acid (FFA) toxicity, thus dysregulating hepatic lipid metabolism. Here, we demonstrate that decreased prolactin (PRL) levels are involved in the association between FFA and MASLD based on a liver biospecimen-based cohort. Moreover, overloaded FFAs decrease serum PRL levels, thus promoting liver steatosis in mice with both dynamic diet intervention and stereotactic pituitary FFA injection. Mechanistic studies show that excessive FFA sensing in pituitary lactotrophs inhibits the synthesis and secretion of PRL in a cell-autonomous manner. Notably, inhibiting excessive lipid uptake using pituitary stereotaxic virus injection or a specific drug delivery system effectively ameliorates hepatic lipid accumulation by improving PRL levels. Targeted inhibition of pituitary FFA sensing may be a potential therapeutic target for liver steatosis.
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