生物
免疫疗法
癌症免疫疗法
小RNA
免疫系统
癌症
计算生物学
免疫
肿瘤微环境
癌症研究
免疫学
生物信息学
基因
遗传学
作者
Wenjie Zhang,Xu Chen,Zhipeng Yang,Jingyu Zhou,Wei Liu,Xuan Zhang,Haimin Li,Shibin Qu,Kaishan Tao
标识
DOI:10.1186/s12943-024-02082-z
摘要
Circular RNAs (circRNAs) are unique noncoding RNAs that have a closed and stable loop structure generated through backsplicing. Due to their conservation, stability and tissue specificity, circRNAs can potentially be used as diagnostic indicators and therapeutic targets for certain tumors. Many studies have shown that circRNAs can act as microRNA (miRNA) sponges, and engage in interactions with proteins and translation templates to regulate gene expression and signal transduction, thereby participating in the occurrence and development of a variety of malignant tumors. Immunotherapy has revolutionized the treatment of cancer. Early researches have indicated that circRNAs are involved in regulating tumor immune microenvironment and antitumor immunity. CircRNAs may have the potential to be important targets for increasing sensitivity to immunotherapy and expanding the population of patients who benefit from cancer immunotherapy. However, few studies have investigated the correlation between circRNAs and tumor immunity. In this review, we summarize the current researches on circRNAs involved in antitumor immune regulation through different mechanisms and their potential value in increasing immunotherapy efficacy with the goal of providing new targets for cancer immunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI