胶束
紫杉醇
壳聚糖
荧光
药物输送
两亲性
体内
生物物理学
材料科学
聚合物
毒品携带者
荧光寿命成像显微镜
化学
核化学
纳米技术
组合化学
共聚物
有机化学
癌症
水溶液
医学
量子力学
生物技术
内科学
物理
生物
作者
Peiyun Cheng,Na Liang,Wei Zhao,Xian-Feng Gong,Li Wang,Shaoping Sun
标识
DOI:10.1016/j.eurpolymj.2023.111974
摘要
In this study, an amphiphilic polymer mPEG-CS-Bio-Hz-Q with capabilities of near-infrared (NIR) fluorescence imaging, active tumor targeting, minimized protein adsorption and pH-responsive drug release was designed and synthesized. The polymer was served as a micellar carrier for paclitaxel (PTX) delivery. The mean size of PTX-loaded mPEG-CS-Bio-Hz-Q micelles was 123.5 nm. In vitro drug release study indicated the pH-triggered PTX release behavior of the micelles. Cellular uptake study demonstrated that the micelles could be effectively internalized by MCF-7 cells and exhibit bright fluorescence. In vivo investigation illustrated the high antitumor activity and excellent safety of the micelles. The mPEG-CS-Bio-Hz-Q micellar system would be promising candidate for bioimaging and cancer therapy.
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