细胞外小泡
血小板
细胞外
微泡
化学
小泡
医学
细胞生物学
生物
生物化学
膜
小RNA
内科学
基因
作者
Jancy Johnson,Yu‐Wen Wu,Chantelle Blyth,Gregor F. Lichtfuss,Hadi Goubran,Thierry Burnouf
标识
DOI:10.1016/j.tibtech.2020.10.004
摘要
There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.
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