医学
肺移植
特发性肺纤维化
间质性肺病
内科学
结缔组织病
移植
CTD公司
外科
胃肠病学
肺
疾病
自身免疫性疾病
海洋学
地质学
作者
D. Prieto-Peña,Amaya Martínez-Meñaca,Mónica Calderon-Goercke,Víctor Manuel Mora Cuesta,Sonia Fernández-Rozas,David Iturbe-Fernández,José Javier Gómez-Román,J. M. Cifrián-Martínez,Santos Castañeda,José L. Hernández,Miguel A. González‐Gay,R. Blanco
出处
期刊:PubMed
日期:2019-11-07
卷期号:38 (4): 615-620
被引量:2
摘要
Interstitial lung disease (ILD) is a leading cause of mortality in patients with connective tissue diseases (CTD). Lung transplantation has become a viable option for patients with end-stage CTD-ILD. However, patients with CTD are often considered suboptimal candidates for lung transplantation because of concerns of worse outcomes. We assessed post-transplant survival of patients with CTD-ILD compared to patients with idiopathic pulmonary fibrosis (IPF).Medical records of patients who underwent lung transplantation for CTD-ILD at a single referral centre for lung transplantation in Northern Spain between 1998 and 2018 were reviewed. This cohort was compared with patients with IPF (group-matched for age ±3.3 years, transplant year and use of basiliximab induction previous to transplant). Cumulative survival rates after transplantation were estimated by the Kaplan-Meier method and compared between groups using the log-rank test.We studied 26 patients with CTD-ILD and 26 patients with IPF. The underlying diseases of CTD-ILD patients were rheumatoid arthritis (n=9), scleroderma (n=6), Sjögren's syndrome (n=4), ANCA-associated vasculitis (n=3), anti-synthetase syndrome (n=2), and dermatomyositis, systemic lupus erythematosus (1 each). Baseline characteristics were similar in both groups. CTD-ILD patients experienced acute graft rejection less commonly than those with IPF (32.0% vs. 62.5%; p=0.032). However, a non-statistically significant increased frequency of chronic graft rejection was observed in CTD-ILD patients (20.0% vs. 8.3%; p=0.417). In this regard, the 5-year cumulative survival rates after transplantation was reduced in CTD-ILD (42.4% vs. 65.8%) but the difference did not achieve statistical significance (p=0.075).Long-term post-transplant survival in Northern Spanish patients with CTD-ILD is reduced compared with IPF.
科研通智能强力驱动
Strongly Powered by AbleSci AI