In vitro-in vivo correlation (IVIVC) of solid lipid nanoparticles loaded with poorly water-soluble drug lovastatin

• LOV-SLNs were successfully formulated by the solvent diffusion GTP as lipid carrier. • The CCRD model proved to be an effective tool in predicting the optimized formulation. • The relative bioavailability of LOV-SLNs demonstrated 269.16% after oral administration in rabbit. • The oral toxicity study in rats demonstrated that the animals were alive through the experiment. • The IVIVC study suggested a good level-A correlation with a correlation coefficient (R 2 ) value of 0.902.