视网膜
光学相干层析成像
医学
神经丛
神经纤维层
眼科
光学相干断层摄影术
光盘
解剖
作者
Ana Marta,Luísa Malheiro,João Coelho,João Poças,Nadine Gonçalves,Paulo Sousa,Ana Figueiredo,Maria Araújo,Sofia Maia,Vasco Miranda,Ricardo Parreira,Pedro Menéres
出处
期刊:Retina-the Journal of Retinal and Vitreous Diseases
[Ovid Technologies (Wolters Kluwer)]
日期:2020-04-29
卷期号:41 (2): 366-372
被引量:3
标识
DOI:10.1097/iae.0000000000002840
摘要
Purpose: To compare the retinal vasculature characteristics between eyes of patients with and without phacomatosis. Methods: Case–control observational study with retinal vasculature evaluation by optical coherence tomography and optical coherence tomography angiography of the macula and disk. Results: The study included 80 eyes. Neurofibromatosis Type 1 patients presented with a higher central macular thickness ( P = 0.007), a lower optical disk nervous fiber layer ( P = 0.006), a lower perimeter, area, and circularity of the foveal avascular zone ( P < 0.05), a higher vascular density of macular avascular layer (AMVD) ( P = 0.004), and a lower papillary vascular density of superficial capillary plexus (SPVD) ( P = 0.048). Patients with tuberous sclerosis presented with an increase in central macular thickness ( P = 0.024) and in vascular densities ( P < 0.05) [except for macular vascular density of deep capillary plexus (PMVD), AMVD, and SPVD]. Patients with Sturge–Weber syndrome showed a decrease in optical disk nervous fiber layer ( P < 0.001), subfoveal choroid thickness ( P = 0.011), macular vascular density of superficial capillary plexus (SMVD) ( P = 0.036), and SPVD ( P < 0.001). Conclusion: Phacomatosis patients showed statistically significant differences of retinal vasculature characteristics, compared to eyes without pathology. Further studies are needed to determine when and if these parameters change with the course of the disease and if they can be used as biomarkers for disease severity or progression.
科研通智能强力驱动
Strongly Powered by AbleSci AI