医学
甲氨蝶呤
相伴的
不利影响
皮疹
皮质类固醇
外科
内科学
药物治疗
作者
Aydintug Ao,David D’Cruz,Ricardo Cubedo Cervera,M. A. Khamashta,Hughes Gr
出处
期刊:PubMed
日期:1992-03-01
卷期号:19 (3): 431-5
被引量:19
摘要
Six patients with adult Still's disease who had either failed to respond to or had adverse effects from previous therapy were given weekly low dose methotrexate (MTX) therapy. They were followed for 4-28 months (mean 14 +/- 9 months). At 12 months of therapy 3 patients were evaluated as having a complete response. One patient had a partial response to MTX after 7 months. Therapy was discontinued in 1 patient at 4 months due to flares of rash and arthralgias after each MTX administration. One patient failed to respond to therapy despite maximum dosage, but was able to reduce his corticosteroid dose. MTX may be a useful therapy to consider in patients with adult Still's disease who are resistant to conventional therapy and may allow a reduction in the concomitant dose of corticosteroids.
科研通智能强力驱动
Strongly Powered by AbleSci AI