化学
订单(交换)
结晶学
X射线
肽
三聚体
X射线晶体学
衍射
有机化学
物理
光学
二聚体
生物化学
财务
经济
作者
Ryan K. Spencer,Hao Li,James S. Nowick
摘要
A peptide derived from Aβ17-36 crystallizes to form trimers that further associate to form higher-order oligomers. The trimers consist of three highly twisted β-hairpins in a triangular arrangement. Two trimers associate face-to-face in the crystal lattice to form a hexamer; four trimers in a tetrahedral arrangement about a central cavity form a dodecamer. These structures provide a working model for the structures of oligomers associated with neurodegeneration in Alzheimer's disease.
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