胺化
化学
分子间力
催化作用
碘
有机合成
组合化学
还原胺化
有机化学
分子
作者
Alexandra E. Bosnidou,Kilian Muñiz
标识
DOI:10.1002/anie.201901673
摘要
Abstract The direct amination of aliphatic C−H bonds has remained one of the most tantalizing transformations in organic chemistry. Herein, we report on a unique catalyst system, which enables the elusive intermolecular C(sp 3 )−H amination. This practical synthetic strategy provides access to aminated building blocks and fosters innovative multiple C−H amination within a new approach to aminated heterocycles. The synthetic utility is demonstrated by the synthesis of four relevant pharmaceuticals.
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