Naturally occurring macromolecular materials can be turned to value-added resources for applications in oil and gas production. The use of these materials has become necessary due to the environmental requirements that are associated with the disposal of oilfield chemicals after usage, sustainability of raw materials for producing the chemicals, and the need for reducing the overall cost of hydrocarbon production. This review presents the applications of natural polymers in oilfield operations including drilling, enhanced oil recovery, and water and gas shut-off.