Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

血压生物全基因组关联研究遗传建筑学遗传学脉冲压力数量性状位点疾病单核苷酸多态性内科学基因型医学基因内分泌学

作者

Εvangelos Εvangelou,Helen R. Warren,David Mosén-Ansorena,Borbála Mifsud,Raha Pazoki,Ruifang Li‐Gao,Georgios Ntritsos,Niki Dimou,Claudia Langenberg,İbrahim Karaman,Fern Lan Ng,Marina Evangelou,Kate Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,K. Cho,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kövesdy,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,F. Giulianini,Elizabeth Holliday,A. U. Jackson,Ruifang Li‐Gao,Wei‐Yu Lin,Jian’an Luan,Massimo Mangino,Christopher Oldmeadow,Bram Prins,Thomas Meitinger,Muralidharan Sargurupremraj,Nabi Shah,Praveen Surendran,Sébastien Thériault,Niek Verweij,Stefan M. Willems,Jinghua Zhao,Philippe Amouyel,John Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Cristina Menni,Raymond Noordam,Guillaume Paré,Neil R Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,C. M. Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Dorret I. Boomsma,Erwin P. Böttinger,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Hemingway,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Eco J. C. de Geus,Cumhur Yusuf Demirkale,Marcus Dörr,G. Ehret,Roberto Elosúa,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,M. Franberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Alan J. Gow,Vilmundur Guðnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Andrew A. Hicks,Ivana Kolčić,Albert Hofman,Jouke‐Jan Hottenga,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Anthony James,Rick Jansen,Marjo‐Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Bernard Keavney,Kay‐Tee Khaw,Paul Knekt,Jo Knight,Ivana Kolčić,Jaspal S. Kooner,Barbara Franke,Kati Kristiansson,Zoltán Kutalik,Maris Laan,Martin G. Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Lin Li,Lars Lind,Cecilia M. Lindgren,Y. Liu,Ruth J. F. Loos,Lorna M. Lopez,Yong‐Jie Lu,Leo‐Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Teemu Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Mark I. McCarthy,Paul F. O’Reilly,Elin Org,Sandosh Padmanabhan,Walter Palmas,Aarno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Annette Peters,Ozren Polašek,Peter P. Pramstaller,Quang Tri Nguyen,Olli T. Raitakari,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M Ridker,Janina S. Ried,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Jerome I. Rotter,Igor Rudan,Daniela Ruggiero,Yasaman Saba,Camila Sala,Veikko Salomaa,Nilesh J. Samani,A. P. Sarin,Joanna M. Wardlaw,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert Hofman,Harold Snieder,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Maciej Tomaszewski,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne‐Claire Vergnaud,Germaine C. Verwoert,Véronique Vitart,Uwe Völker,Péter Vollenweider,Dragana Vuckovic,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weidong Zhang,John Attia,Adam S. Butterworth,D. I. Chasman,David Conen,Francesco Cucca,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Olle Melander,Dennis O. Mook‐Kanamori,Colin N. A. Palmer,Lorenz Risch,Rodney J. Scott,Peter Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Daniel Lévy,Patricia B. Munroe,Christopher Newton‐Cheh,Morris J. Brown,Andres Metspalu,Adriana M. Hung,Christopher P. Nelson,Todd L. Edwards,Bruce M. Psaty,Ioanna Tzoulaki,Michael R. Barnes,Louise V. Wain,Paul Elliott,Mark J. Caulfield

出处

期刊：Nature Genetics [Springer Nature]
日期：2018-09-17 卷期号：50 (10): 1412-1425 被引量：1018

标识

DOI：10.1038/s41588-018-0205-x

摘要

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

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