抗体
医学
治疗方法
免疫学
自身免疫
炎症
疾病
病理
作者
Andrew C. Chan,Paul J. Carter
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2010-04-23
卷期号:10 (5): 301-316
被引量:792
摘要
The development of therapeutic antibodies has evolved over the past decade into a mainstay of therapeutic options for patients with autoimmune and inflammatory diseases. Substantial advances in understanding the biology of human diseases have been made and tremendous benefit to patients has been gained with the first generation of therapeutic antibodies. The lessons learnt from these antibodies have provided the foundation for the discovery and development of future therapeutic antibodies. Here we review how key insights obtained from the development of therapeutic antibodies complemented by newer antibody engineering technologies are delivering a second generation of therapeutic antibodies with promise for greater clinical efficacy and safety.
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