生物
奶油
转录因子
辅活化剂
CREB结合蛋白
转化(遗传学)
DNA结合蛋白
细胞生物学
抄写(语言学)
遗传学
计算生物学
基因
语言学
哲学
作者
Richard H. Goodman,Sarah M. Smolik
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory Press]
日期:2000-07-01
卷期号:14 (13): 1553-1577
被引量:1717
标识
DOI:10.1101/gad.14.13.1553
摘要
CREB binding protein (CBP) and p300 were both identified initially in protein interaction assays-the former through its association with the transcription factor CREB (Chrivia et al. 1993) and the latter through its interaction with the adenoviral-transforming protein E1A (Stein et al. 1990;Eckner et al. 1994).The recognition that these two proteins, one involved in transcription and the other in cell transformation, had highly conserved sequences suggested that they had the potential to participate in a variety of cellular functions (Fig. 1).Several excellent reviews (Janknecht and Hunter 1996;Shikama et al. 1997;Giles et al. 1998) have addressed the transcriptional coactivator functions of CBP/p300; this review focuses on the involvement of these proteins in the complex biological processes that affect cell growth, transformation, and development.
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