橙皮素
阿魏酸
甾醇O-酰基转移酶
化学
橙皮苷
胆固醇
生物化学
类黄酮
脂蛋白
抗氧化剂
医学
病理
替代医学
作者
Hae‐Kyung Kim,Tae‐Sook Jeong,Mi‐Kyung Lee,Yong Bok Park,Myung‐Sook Choi
标识
DOI:10.1016/s0009-8981(02)00344-3
摘要
Background: Hesperetin is a naturally occurring flavonoid that has hypolipidemic properties. Methods: Male rats were fed a 1 g/100 g high-cholesterol diet for 5 weeks along with hesperetin (0.02%, 0.066 mmol/100 g diet) and hesperetin metabolites. The hesperetin metabolites, m-hydroxycinnamic acid (m-HC), 3,4-dihydroxyphenylpropionic acid (3,4-DHPP), and 3-methoxy-4-hydroxycinnamic acid (ferulic acid), were supplemented based on an equivalent amount of hesperetin. Results: The supplementation of hesperetin and its metabolites significantly lowered the plasma total cholesterol and triglyceride concentrations compared to the control group. The hepatic HMG-CoA reductase and acyl-CoA:cholesterol acyltransferase (ACAT) activities were significantly lower in the hesperetin and its metabolite supplemented groups than in the control group. The excretion of acidic sterol was significantly higher in the hesperetin, m-HC, 3,4-DHPP, and ferulic acid supplemented groups than in the control group. Conclusions: These results demonstrated that the hesperetin metabolites played as potent a role as hesperetin in plasma lipid-lowering activities in vivo, and further suggest that cholesterol biosynthesis and esterification were concomitantly reduced by hesperetin and its metabolites, as indicated by the decreased HMG-CoA reductase and ACAT activities.
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