生物污染
涂层
纤维蛋白
血栓形成
材料科学
生物医学工程
体外
粘附
图层(电子)
表面改性
纳米技术
医学
化学
外科
复合材料
免疫学
物理化学
生物化学
膜
作者
Daniel C. Leslie,Anna Waterhouse,Julia Hicks‐Berthet,Thomas Valentin,Alexander L. Watters,Abhishek Jain,Philseok Kim,Benjamin D. Hatton,Arthur Nedder,Kathryn Donovan,Elana H. Super,Caitlin Howell,Christopher Johnson,Thy L. Vu,Dana E Bolgen,Sami W. Rifai,Anne Hansen,Michael Aizenberg,Michael Super,Joanna Aizenberg,Donald E. Ingber
摘要
A non-stick surface coating makes medical devices anti-thrombogenic and resistant to biofilm growth. Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
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